Monsanto has sued many farmers when their GM crops have turned up in the farmer's fields even though the farmers state they never planted them. Farmers who get into the Roundup-Ready (RR) System lose their independence, and are obliged to sign a lengthy and restrictive agreement.

Monsanto often contracts private investigation firms like Pinkerton, to check up on farmers and independent, non-GM farmers, taking samples unannounced from their fields to make sure they are not in violation. Monsanto also maintains a hotline so farmers can turn in their neighbours for suspected violations.